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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
21.82
Human Site:
S420
Identified Species:
34.29
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S420
A
T
F
V
V
G
N
S
S
L
L
D
T
S
S
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S420
A
T
F
V
V
G
N
S
S
L
L
D
T
S
S
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
A420
A
T
F
V
V
G
N
A
S
L
L
D
T
S
S
Dog
Lupus familis
XP_536323
888
97475
S420
A
T
F
V
V
G
N
S
S
L
L
D
T
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
S420
A
T
F
V
L
G
A
S
V
A
S
P
P
S
A
Rat
Rattus norvegicus
P51639
887
96670
S420
A
T
F
V
L
G
A
S
A
A
S
P
P
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
C407
A
T
F
V
V
G
S
C
N
P
E
E
T
S
S
Frog
Xenopus laevis
P20715
883
96702
S417
A
K
F
I
V
G
D
S
S
P
L
E
L
S
P
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
D428
S
T
F
V
L
G
E
D
E
T
Q
E
N
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
I461
R
H
R
L
V
G
P
I
K
P
P
R
P
V
Q
Honey Bee
Apis mellifera
XP_623118
908
99432
S431
K
Q
C
T
V
N
T
S
N
D
K
N
L
F
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
S433
F
T
I
G
S
S
G
S
G
S
E
D
E
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
G164
I
V
A
S
V
V
A
G
K
V
P
S
Y
A
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
K177
E
E
D
E
E
I
V
K
S
V
I
D
G
V
I
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
S577
S
S
A
Q
S
S
S
S
G
P
S
S
S
S
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
93.3
93.3
N.A.
46.6
40
N.A.
N.A.
60
53.3
26.6
N.A.
13.3
20
N.A.
20
P-Site Similarity:
100
100
100
93.3
N.A.
60
60
N.A.
N.A.
80
73.3
53.3
N.A.
20
33.3
N.A.
20
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
6.6
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
54
0
14
0
0
0
20
7
7
14
0
0
0
7
14
% A
% Cys:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
7
7
0
7
0
40
0
0
0
% D
% Glu:
7
7
0
7
7
0
7
0
7
0
14
20
7
7
14
% E
% Phe:
7
0
60
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
0
0
7
0
67
7
7
14
0
0
0
7
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
0
7
7
0
7
0
7
0
0
7
0
0
0
7
% I
% Lys:
7
7
0
0
0
0
0
7
14
0
7
0
0
0
0
% K
% Leu:
0
0
0
7
20
0
0
0
0
27
34
0
14
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
27
0
14
0
0
7
7
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
27
14
14
20
0
7
% P
% Gln:
0
7
0
7
0
0
0
0
0
0
7
0
0
0
7
% Q
% Arg:
7
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
14
7
0
7
14
14
14
60
40
7
20
14
7
54
34
% S
% Thr:
0
60
0
7
0
0
7
0
0
7
0
0
34
7
0
% T
% Val:
0
7
0
54
60
7
7
0
7
14
0
0
0
14
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _